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Seroquel side effects Get emergency medical help if you have signs of an allergic reaction to Seroquel: hives, difficult breathing, swelling of your face, lips, tongue, or throat. High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. The longer you use Seroquel, the more likely you are to develop this disorder, especially if you are a woman or an older adult. Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself. Seroquel may cause serious side effects. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); breast swelling and tenderness, nipple discharge, impotence, missed menstrual periods; trouble swallowing, severe constipation; painful or difficult urination; high blood pressure, fast, slow or uneven heart rate; a light-headed feeling, sudden numbness or weakness, severe headache; blurred vision, eye pain or redness, seeing halos around lights; a seizure, feeling unusually hot or cold; signs of infection - fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out; underactive thyroid - tiredness, depressed mood, dry skin, thinning hair, decreased sweating, weight gain, puffiness in your face, feeling more sensitive to cold temperatures; high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough. Common Seroquel side effects may include: speech problems; dizziness, drowsiness, tiredness; feeling like you might pass out; lack of energy; fast heartbeats; increased appetite, weight gain; upset stomach, vomiting, constipation; stomach pain, nausea; abnormal liver function tests, sore throat; stuffy nose, dry mouth; or difficulty moving. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.